Senior Principal Scientist Quantum Mechanics and Modeling | Senior Principal Scientist Quantum Mechanics and Modeling (m/f/d)

Bayer AG Pharmaceuticals

Wuppertal, Nordrhein-Westfalen, Deutschland
Published Mar 20, 2026
Full-time
No information

Job Summary

As a Senior Principal Scientist, you will be a central figure in Bayer's R&D digital transformation, utilizing quantum mechanics, physics-based modeling, and AI to revolutionize drug discovery. Your daily activities will involve predicting molecular properties and designing compounds to advance discovery project milestones. You will work in a highly collaborative environment alongside medicinal chemists, biologists, and data engineers to enable AI-augmented Design-Make-Test-Analyze (DMTA) cycles. Beyond technical execution, you will lead strategic digital initiatives, co-shape R&D strategy, and mentor junior colleagues. This role is particularly attractive for its blend of high-level scientific research and strategic leadership within a global pharmaceutical leader. It offers significant flexibility with hybrid work options, a competitive salary package, and the opportunity to work on cutting-edge technologies like generative design and high-performance computing to solve real-world health challenges.

Required Skills

Education

PhD in Quantum Chemistry, Computational Chemistry, Chemistry, Computer Science, or a related discipline with strong knowledge of organic chemistry.

Experience

  • Extensive professional experience in an industrial pharmaceutical or biotech setting
  • Demonstrated success in utilizing a diverse range of ligand- and structure-based modeling approaches
  • Proven experience with AI-driven DMTA loops within a pharma environment
  • Experience in leading strategic digital initiatives and shaping R&D digital strategy
  • Experience in coaching, mentoring, and teaching scientific staff

Languages

English (Fluent)

Additional

  • Location: Wuppertal-Aprath, Germany. Role allows for full-time or near full-time (minimum 80%) work arrangements. Candidates must align with Bayer's leadership standards and holistic health principles.