Doctoral Researcher – Mechanobiology of Parasitic Interactions in a Worm-on-Chip Model | Doktorand – Mechanobiologie parasitärer Interaktionen im Worm-on-Chip-Modell (m/w/d)

Job Summary

This doctoral position offers a unique opportunity to conduct experimental research on the mechanobiological interactions between parasites and host cells within a DFG-funded priority program. The successful candidate will develop and apply a "worm-on-chip" model to investigate the suction forces of parasitic flatworms (Schistosoma mansoni and Fasciola hepatica) on human host cells. Key responsibilities include cultivating and co-culturing liver and endothelial cell lines on hydrogel-functionalized surfaces, performing Traction Force Microscopy (TFM) and Monolayer Stress Microscopy (MSM) to quantify parasitic forces, and analyzing mechanosensitive signaling pathways via calcium imaging and molecular biology techniques. This interdisciplinary project aims to gain new insights into the pathogenic effects of mechanical forces in worm infections and develop innovative host-pathogen interaction models, utilizing modern lab equipment and structured doctoral supervision.