Postdoctoral Researcher in Generative AI for De Novo Protein Design | Postdoc (f/m/d) on Generative AI for de Novo Protein Design

HELMHOLTZ-ZENTRUM DRESD EN-ROSSENDORF E.V.

Dresden, Sachsen, Deutschland
Published Dec 15, 2025
Full-time
Fixed-term

Job Summary

This Postdoctoral Researcher role at the Center for Advanced Systems Understanding (CASUS) focuses on applying cutting-edge Generative AI models, such as VAEs, GANs, and Diffusion Models, to create novel protein sequences, fold structures, and functional molecules. The successful candidate will be responsible for designing and implementing these models, collaborating extensively with international research partners (including teams in Berlin, London, and Zurich), and contributing to broader machine learning and functional genomics research within the department. Key qualifications include a completed PhD in computational or molecular biology, strong programming skills in Python and C/C++, and mandatory experience with High-Performance Computing (HPC) and Slurm cluster environments. This position offers the chance to work in a vibrant, international research community, publish high-impact peer-reviewed research, and supervise junior lab members, making it an excellent opportunity for a motivated scientist passionate about the intersection of AI and structural biology.

Required Skills

Education

PhD in Molecular Biology, Computational Biology, Bioinformatics, Genetics, Computer Science, Mathematics, or equivalent scientific background

Experience

  • Completed university studies (PhD) in molecular biology, computational biology, bioinformatics, genetics, computer science, mathematics, or equivalent scientific background
  • Mandatory experience with High-Performance Computing (HPC) cluster environments and the Slurm cluster environment
  • Experience or interest in Generative Modelling, Protein Folding/Design, and Structural Biology (a plus)
  • Experience with AlphaFold, RFdiffusion, and RFdiffusion2 (a significant plus)
  • Experience supervising junior lab members

Languages

English (Fluent)

Additional

  • Contract duration limited to 36 months.