Technical Assistant - In-vivo Models / Immunotherapy / Genetic Engineering | Technische:n Assistent:in (m/w/d) – In-vivo-Modelle / Immuntherapie / Genetic Engineering

Deutsches Krebsforschungszentrum

Heidelberg, Neckar, Baden-Württemberg, Deutschland
Published Oct 14, 2025
Full-time
Fixed-term

Job Summary

This role is for a highly motivated Technical Assistant to join the Pediatric Immuno-oncology research group, focusing on advancing CAR-T cell therapies for solid childhood tumors. The successful candidate will play a key role in designing, executing, and optimizing in-vivo studies using xenograft and syngeneic mouse models to investigate CAR-T cell interactions and efficacy. Day-to-day tasks involve extensive in-vivo experimentation, integrating in-vitro and ex-vivo assays such as flow cytometry and functional analyses (cytotoxicity, cytokine release), and applying genetic engineering techniques including CRISPR/Cas9 modification and viral transduction. The position requires a completed technical qualification (BTA, MTA, or equivalent), excellent organizational skills, and a strong willingness to conduct in-vivo studies while strictly adhering to animal welfare guidelines. This is an exciting opportunity to contribute to cutting-edge cancer research within one of Europe's largest centers, offering modern infrastructure and collaborative work with postdocs and students.

Required Skills

Education

Completed training as a BTA (Biological Technical Assistant), MTA (Medical Technical Assistant), Biology Laboratory Technician, or comparable qualification

Experience

  • Experience in handling laboratory animals and performing in-vivo procedures (advantageous)
  • Experience in cloning, CRISPR/Cas gene editing, viral transduction, CAR-T cells, and primary cell culture (desirable)
  • Professional experience in laboratory organization and maintenance

Languages

German (Fluent)English (Fluent)

Additional

  • Must provide proof of immunity against measles (due to Infektionsschutzgesetz/IfSG requirements); Initial contract duration of 2 years (temporary position); Submission of a cover letter (1 page) and CV in a single PDF file required.