Senior Scientist - RNA Mass Spectrometry | Chemist (m/w/d)
BioNTech SE
Job Summary
The Senior Scientist will join the expanding Analytical Development department in Munich-Martinsried, Germany, focusing on designing, developing, and implementing state-of-the-art mass spectrometry (MS) assays for characterizing therapeutic messenger RNA (mRNA). This technical leadership role involves leading the development and optimization of high-resolution LC-MS methods (e.g., Orbitrap, TIMS-TOF) to analyze intact mRNA, oligonucleotide fragments, and related impurities. A core function is translating research-grade methods into phase-appropriate, GMP-compliant assays, including drafting validation plans and analytical reports for critical regulatory submissions (IND/CTA, BLA/MAA). The successful candidate will act as a subject matter expert (SME), supporting regulatory filings and providing technical mentorship to junior scientists. This position requires a Ph.D. or equivalent experience in Chemistry or related disciplines, coupled with over 10 years of extensive experience in high-resolution MS, with a specific focus on nucleic acids.
Required Skills
Education
Ph.D. (or equivalent industrial experience) in Chemistry, Biochemistry, Pharmaceutical Sciences, Molecular Biology, or related discipline
Experience
- ≥ 10 years extensive knowledge in method development and data acquisition and analysis with high-resolution mass spectrometers
- At least 2 years focused on RNA, oligonucleotide, or nucleic-acid-based therapeutics
- Professional experience translating research-grade methods into phase-appropriate, GMP-compliant assays
- Demonstrated ability to solve complex problems and successfully manage projects from initiation to completion
Languages
Additional
- Working knowledge of ICH, USP, Ph. Eur., and FDA/EMA expectations for analytical methods and GMP laboratories
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